Two Zn(II)-organic frameworks: catalytic Knoevenagel condensation and treatment activity on spine surgery incision infection via inhibiting <i>Staphylococcus aureus</i> biofilms formation

By utilizing the mixed-ligand method, two novel metal-organic frameworks (MOFs) based on Zn(II) ions as nodes with chemical formulae of {[Zn2.5(abta)(trz)2(H2O)]·3H2O}n (1, Htrz = 1H-1,2,4-triazole) and [Zn3(abta)2(bibb)2]n (2, bibb 1,4-bis(benzimidazol-1-yl)-2-butene) were produced via Zn(NO3)2·6H2O reacting 1-aminobenzene-3,4,5-tricarboxylic acid (H3abta) in existence distinct nitrogen-donor co-ligands. The different N-donor ligands result their framework structures, compound 1 higher solvent accessible void large window size shows highly heterogeneous catalytic activities for Knoevenagel condensation. treatment Staphylococcus aureus biofilms formation during spine surgery incision infection related mechanism was explored at same time. First all, S. bacterial numbers infectious site measured under or 2 treatment. In addition to this, relative expression levels genes determined real time RT-PCR.